Podcasts - For your listening pleasure

[Dr_SLO]

TWiV 710 contains COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.

Links for this episode

• Evaluation of Abbott BinaxNOW (MMWR) 17:00
• Lilly mAb in nursing homes (WSJ) 18:16
• Vitamin D and COVID-19 severity (Mayo Clin Proc) 19:56
• Anticoagulation, aspirin, in-hospital mortality in COVID-19 (medRxiv) 21:19
• Long COVID symptoms in outpatients (Ann Int Med) 27:07
• {url=https://www.microbe.tv/twiv/twiv-710-letters/]Letters read[/url] on TWiV 710 27:48
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 711, the TWiVers review Biden’s national strategy for COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.

Links for this episode

• Biden’s COVID-19 strategy (pdf) 10:30
• CDC evaluation of BinaxNOW antigen test (MMWR) 52:09
• FDA instructions for BinaxNOW test (pdf) 52:28
• Adam Neely on Sea Shanties (YouTube) 1:05:29
• Letters read on TWiV 711 1:06:55
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 712, Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.

Links for this episode

• German Society for Virology 2:42, 1:35:26
• Ticks in Germany and TBEV (Sci Rep) 1:05:20
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In COVID-19 clinical update #47 (TWiV 713), Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.

Links for this episode

• Novavax vaccine phase 3 results (Novavax) 1:37
• J&J vaccine phase 3 results (J&J) 4:58
• COVID-19 and transmission in K-12 schools (MMWR) 18:38
• Lilly mAb therapy (NEJM) 20:18
• Regeneron mAb prophylaxis (Regeneron) 21:54
• Colchicine for COVID-19 (Cardiol Today) 24:45
• Letters read on TWiV 713 28:32
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 714, Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Links for this episode

• Prefusion spike structure (Science) 3:27, 10:29
• Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer 57:48
• Novavax COVID-19 vaccine phase 3 results (Novavax) 1:15:41
• J&J COVID-19 vaccine phase 3 results (J&J) 1:27:48
• B.1.1.7 has been in the US since November 2020 (virological.org) 1:37:27
• NERVTAG report on B.1.1.7 virulence (pdf) 1:46:57
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 715, TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.

Links for this episode

• TMPRSS2 is why hydroxychloroquine failed (PLoS Path) 3:58
• Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) 39:48
• Letters read on TWiV 715 1:05:10
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In TWiV's COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

Links for this episode

• Resistance of variants to mAb neutralization (bioRxiv) 14:45
• Safety and efficacy of Sputnik V (Lancet) 19:00
• Increased vaccine reactogenicity in seropositives (medRxiv) 23:05
• Single dose vaccination in seropositive health care workers (medRxiv) 24:18
• Update on vaccine intervals (CDC) 25:48
• Single dose AZD1222 results (Lancet preprints) 34:02
• Three RCT on anticoagulants (NIH) 34:44
• Letters read on TWiV 716 44:48
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In TWiV 717, Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.

Links for this episode

• Evolution of antibody immunity to SARS-CoV-2 (bioRxiv) 48:43
• mRNA vaccine elicited antibody to variants (bioRxiv)
• Escape from neutralizing antibodies by SARS-CoV-2 variants (eLife) 55:53
• Musings of an anonymous, pissed off virologist (virology blog) 1:34:05
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 218, TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.

Links for this episode

• AZD1222 single dose efficacy and booster timing (Lancet preprint) 2:17
• Safety and efficacy of Sputnik V vaccine (Lancet) 26:14
• Proofreading exonuclease regulates CoV recombination (PLoS Path) 39:20
• Letters read on TWiV 718 1:08:13
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.

Links for this episode

• Resurgence of COVID-19 in Brazil (Lancet) 7:41
• Pfizer vaccine reduces viral load (medRxiv) 10:34
• EUA for bamlanivimab plus etesevimab (pdf) 12:58
• Tocilizumab in hospitalized patients (medRxiv) 14:54
• Bacterial superinfections in COVID-19 (Open For Inf Dis) 17:08
• Letters read on TWiV 719 21:16
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 720, Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

Links for this episode

• Vaccine education center 5:37
• Letters read on TWiV 720 1:00:27
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.

Links for this episode

• Guidance on school openings (CDC) 1:41
• Calcifediol Treatment and COVID-19 (Lancet preprints) 6:24
• Zinc and vitamin C for COVID-19 (JAMA) 9:22
• Early anticoagulant therapy (BMJ) 10:45
• Multisystem inflammatory phase in children (CDC) 15:49
• Letters read on TWiV 721 20:20
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In TWiV 722 the entire team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

Links for this episode

• Resurgence of COVID-19 in Manaus (Lancet) 3:55
• SARS-CoV-2 related viruses in Southeast Asian bats (Nat Comm) 19:17
• Increased Ct following COVID-19 vaccination (medRxiv) 53:34
• Letters read on TWiV 722 1:09:58
• Timestamps by Jolene. Thanks!

[Dr_SLO]

In Episode 723, Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.

Links for this episode

• Brain Science Podcast
• Dr. Campbell’s video on palliative care (YouTube)
• Resources on palliative care (WHO)
• Interviews with Paul Offit (one, two)
• Being Mortal by Atul Gawande
• Letters read on TWiV 723
• Timestamps by Jolene. Thanks!