Sears, Laguna, THill...
Redwood, Highway 9, Alpine...
Seriously though, driving through the SC mountains, then HMB and 1 on the way to the City for something has been surprisingly cool for my visitors. If they're techy or nerdy at all I offer drive-bys of company buildings on the way to something... some of them are cool and Moffett is too. Fry's! I've had some visitors be thrilled with Fry's.
Yosemite, King's Canyon, Avenue of the Giants?
If I'm taking folks to Marin, or further north, I'll try to go by Lake Merced and Ocean Beach. Other touristy stuff: Alamo Square, Twin Peaks is always good, Haight, the Castro, cable cars, going all the way around Treasure Island is good too.
Wine tasting? SC Mts, Napa, Sonoma, Lib'Mo...
Coffee people? Peet's & then on another day North Beach...
Lots of museums (comic book museum?) ... There's a restaurant near there with old motos on the walls too...
GGB > Marin Headlands > back through the lower tunnel...
Movie people? Is there a museum in Niles?
Oh, this could seriously be the best for them: take them to a BARF event. Seeing NorCal and the BA is cool, but knowing who you're hanging out with is important.